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Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate phosphoproteomics, we analyzed heterocellula...

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Detalles Bibliográficos
Autores principales: Tape, Christopher J., Ling, Stephanie, Dimitriadi, Maria, McMahon, Kelly M., Worboys, Jonathan D., Leong, Hui Sun, Norrie, Ida C., Miller, Crispin J., Poulogiannis, George, Lauffenburger, Douglas A., Jørgensen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868820/
https://www.ncbi.nlm.nih.gov/pubmed/27087446
http://dx.doi.org/10.1016/j.cell.2016.03.029