eIF4A inactivates TORC1 in response to amino acid starvation

Amino acids regulate TOR complex 1 (TORC1) via two counteracting mechanisms, one activating and one inactivating. The presence of amino acids causes TORC1 recruitment to lysosomes where TORC1 is activated by binding Rheb. How the absence of amino acids inactivates TORC1 is less well understood. Amin...

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Detalles Bibliográficos
Autores principales: Tsokanos, Foivos‐Filippos, Albert, Marie‐Astrid, Demetriades, Constantinos, Spirohn, Kerstin, Boutros, Michael, Teleman, Aurelio A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868951/
https://www.ncbi.nlm.nih.gov/pubmed/26988032
http://dx.doi.org/10.15252/embj.201593118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868951/
https://www.ncbi.nlm.nih.gov/pubmed/26988032
http://dx.doi.org/10.15252/embj.201593118

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