Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

Regulators of complement activation (RCA) inhibit complement‐induced immune responses on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound to complement component C3b. Our structural data reveal that up to four consecutive...

Descripción completa

Detalles Bibliográficos
Autores principales: Forneris, Federico, Wu, Jin, Xue, Xiaoguang, Ricklin, Daniel, Lin, Zhuoer, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Granneman, Joke CM, Hauhart, Richard, Bertram, Paula, Liszewski, M Kathryn, Atkinson, John P, Lambris, John D, Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868954/
https://www.ncbi.nlm.nih.gov/pubmed/27013439
http://dx.doi.org/10.15252/embj.201593673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868954/
https://www.ncbi.nlm.nih.gov/pubmed/27013439
http://dx.doi.org/10.15252/embj.201593673

Ejemplares similares