Cargando…

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

Regulators of complement activation (RCA) inhibit complement‐induced immune responses on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound to complement component C3b. Our structural data reveal that up to four consecutive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Forneris, Federico, Wu, Jin, Xue, Xiaoguang, Ricklin, Daniel, Lin, Zhuoer, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Granneman, Joke CM, Hauhart, Richard, Bertram, Paula, Liszewski, M Kathryn, Atkinson, John P, Lambris, John D, Gros, Piet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868954/ https://www.ncbi.nlm.nih.gov/pubmed/27013439 http://dx.doi.org/10.15252/embj.201593673

Ejemplares similares

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
por: Lamers, Christina, et al.
Publicado: (2022)

Structural and functional implications of the complement convertase stabilized by a staphylococcal inhibitor
por: Rooijakkers, Suzan H M, et al.
Publicado: (2009)

Structure of C3b-factor H and implications for host protection by complement regulators
por: Wu, Jin, et al.
Publicado: (2009)

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration
por: Carmona-Fontaine, Carlos, et al.
Publicado: (2011)

Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration
por: Haynes, Tracy, et al.
Publicado: (2013)

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b
por: van den Bos, Ramon M., et al.
Publicado: (2019)

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D
por: Forneris, Federico, et al.
Publicado: (2014)

Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding
por: Volokhina, Elena, et al.
Publicado: (2012)

Complement component C3aR constitutes a novel regulator for chick eye morphogenesis
por: Grajales-Esquivel, Erika, et al.
Publicado: (2017)

Complement in Action: An Analysis of Patent Trends from 1976 Through 2011
por: Yang, Kun, et al.
Publicado: (2012)

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling
por: Peng, Weng Chuan, et al.
Publicado: (2013)

Complement regulator CD46: genetic variants and disease associations
por: Liszewski, M. Kathryn, et al.
Publicado: (2015)

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
por: Avirutnan, Panisadee, et al.
Publicado: (2011)

Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets
por: Hamad, Osama A., et al.
Publicado: (2010)

Dengue and the Lectin Pathway of the Complement System
por: Kraivong, Romchat, et al.
Publicado: (2021)

Modulation of the anti-tumor immune response by complement
por: Markiewski, Maciej M., et al.
Publicado: (2008)

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1
por: Avirutnan, Panisadee, et al.
Publicado: (2010)

Treatment of Spinal Cord Injury with Intravenous Immunoglobulin G: Preliminary Evidence and Future Perspectives
por: Tzekou, Apostolia, et al.
Publicado: (2014)

The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo
por: Liu, Jianuo, et al.
Publicado: (2005)

Editorial: Complement and Immunotherapeutics
por: Okrój, Marcin, et al.
Publicado: (2021)

Complexity of complement activation in sepsis
por: Markiewski, Maciej M, et al.
Publicado: (2008)

The Challenges and Promise of Complement Therapeutics for Ocular Diseases
por: Park, Dong Ho, et al.
Publicado: (2019)

Complementing the Cancer-Immunity Cycle
por: Pio, Ruben, et al.
Publicado: (2019)

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
por: Oosterheert, Wout, et al.
Publicado: (2018)

Response to “Comment on Mastellos and colleagues and efficacy of complement-targeting drugs in COVID-19”
por: Mastellos, Dimitrios C., et al.
Publicado: (2021)

Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function
por: Olsen, Ingar, et al.
Publicado: (2017)

Effects of experimental cervical spinal cord injury on peripheral adaptive immunity
por: Ulndreaj, Antigona, et al.
Publicado: (2020)

Complement & disease: out of the shadow into the spotlight
por: Ricklin, Daniel, et al.
Publicado: (2021)

Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads
por: Mastellos, Dimitrios C., et al.
Publicado: (2020)

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry
por: Rodenburg, Remco N. P., et al.
Publicado: (2017)

Tipping the balance: intricate roles of the complement system in disease and therapy
por: Pouw, Richard B., et al.
Publicado: (2021)

Efficacy matters: broadening complement inhibition in COVID-19
por: Mastellos, Dimitrios C, et al.
Publicado: (2021)

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

Complement as a target in COVID-19?
por: Risitano, Antonio M., et al.
Publicado: (2020)

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria
por: Tetteh-Quarcoo, Patience B., et al.
Publicado: (2012)

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort
por: Salmon, Jane E., et al.
Publicado: (2011)

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

The Complement System Is Critical in Maintaining Retinal Integrity during Aging
por: Mukai, Ryo, et al.
Publicado: (2018)

Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections
por: Liszewski, M Kathryn, et al.
Publicado: (2021)

In Vivo Role of Complement-Interacting Domains of Herpes Simplex Virus Type 1 Glycoprotein Gc
por: Lubinski, John, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_6b6aenlc9h8j4ed1tgcj4k1t68