Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

SUMO and ubiquitin play important roles in the response of cells to DNA damage. These pathways are linked by the SUMO Targeted ubiquitin Ligase Rnf4 that catalyses transfer of ubiquitin from a ubiquitin loaded E2 conjugating enzyme to a polySUMO modified substrate. Rnf4 can functionally interact wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Maure, Jean-François, Moser, Sandra C., Jaffray, Ellis G., F. Alpi, Arno, Hay, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868978/
https://www.ncbi.nlm.nih.gov/pubmed/27185577
http://dx.doi.org/10.1038/srep26178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868978/
https://www.ncbi.nlm.nih.gov/pubmed/27185577
http://dx.doi.org/10.1038/srep26178

Ejemplares similares