MicroRNA-27a Induces Mesangial Cell Injury by Targeting of PPARγ, and its In Vivo Knockdown Prevents Progression of Diabetic Nephropathy

MicroRNAs play important roles in the pathogenesis of diabetic nephropathy (DN). In this study, we found that high glucose upregulated miR-27a expression in cultured glomerular mesangial cells and in the kidney glomeruli of streptozotocin (STZ)-induced diabetic rats. miR-27a knockdown prevented high...

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Detalles Bibliográficos
Autores principales: Wu, Lina, Wang, Qingzhu, Guo, Feng, Ma, Xiaojun, Ji, Hongfei, Liu, Fei, Zhao, Yanyan, Qin, Guijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869109/
https://www.ncbi.nlm.nih.gov/pubmed/27184517
http://dx.doi.org/10.1038/srep26072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869109/
https://www.ncbi.nlm.nih.gov/pubmed/27184517
http://dx.doi.org/10.1038/srep26072

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