Cargando…

MicroRNA-27a Induces Mesangial Cell Injury by Targeting of PPARγ, and its In Vivo Knockdown Prevents Progression of Diabetic Nephropathy

MicroRNAs play important roles in the pathogenesis of diabetic nephropathy (DN). In this study, we found that high glucose upregulated miR-27a expression in cultured glomerular mesangial cells and in the kidney glomeruli of streptozotocin (STZ)-induced diabetic rats. miR-27a knockdown prevented high...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Lina, Wang, Qingzhu, Guo, Feng, Ma, Xiaojun, Ji, Hongfei, Liu, Fei, Zhao, Yanyan, Qin, Guijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869109/ https://www.ncbi.nlm.nih.gov/pubmed/27184517 http://dx.doi.org/10.1038/srep26072

Ejemplares similares

MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy
por: Hou, Xiaoyan, et al.
Publicado: (2016)

MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy
por: Zhou, Zhanmei, et al.
Publicado: (2017)

Correction: MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy
por: Zhou, Zhanmei, et al.
Publicado: (2018)

Hypoxia Mediates Mutual Repression between microRNA-27a and PPARγ in the Pulmonary Vasculature
por: Kang, Bum-Yong, et al.
Publicado: (2013)

FGF21 attenuates hypoxia-induced dysfunction and inflammation in HPAECs via the microRNA-27b-mediated PPARγ pathway
por: Yao, Dan, et al.
Publicado: (2021)

In Vivo Testing of MicroRNA-Mediated Gene Knockdown in Zebrafish
por: Leong, Ivone Un San, et al.
Publicado: (2012)

New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy
por: Jia, Zhanjun, et al.
Publicado: (2014)

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation
por: Thomas, Haryana Y., et al.
Publicado: (2022)

Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells
por: Wu, Jingkui, et al.
Publicado: (2022)

Angpt2 Induces Mesangial Cell Apoptosis through the MicroRNA-33-5p-SOCS5 Loop in Diabetic Nephropathy
por: Tsai, Yi-Chun, et al.
Publicado: (2018)

LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinoma
por: Zhao, Shuiying, et al.
Publicado: (2015)

Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARγ and reducing NOX4 expression
por: Ning, Meng, et al.
Publicado: (2022)

Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China
por: Zhao, Yanyan, et al.
Publicado: (2017)

Warfarin-Related Nephropathy Manifested as Diffuse Mesangial Proliferative Glomerulonephritis
por: Acquah, Frederick, et al.
Publicado: (2022)

Differential expression profile of urinary exosomal microRNAs in patients with mesangial proliferative glomerulonephritis
por: Dai, Rong, et al.
Publicado: (2023)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Nephropathy 1st inhibits renal fibrosis by activating the PPARγ signaling pathway
por: Mu, Linjie, et al.
Publicado: (2022)

NUP160 knockdown inhibits the progression of diabetic nephropathy in vitro and in vivo
por: Xie, Jiayong, et al.
Publicado: (2022)

MicroRNA-27a functions as an oncogene in human osteosarcoma by targeting CCNG1
por: Lin, Tao, et al.
Publicado: (2018)

CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis
por: Fu, Lanfang, et al.
Publicado: (2022)

Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system
por: Toffoli, Barbara, et al.
Publicado: (2017)

Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model
por: Wang, Xin, et al.
Publicado: (2020)

Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
por: Brunskill, Eric W, et al.
Publicado: (2012)

Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice
por: Waasdorp, Maaike, et al.
Publicado: (2018)

NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy
por: Li, Xue, et al.
Publicado: (2022)

The Role of MicroRNAs in Diabetic Nephropathy
por: Wu, Hao, et al.
Publicado: (2014)

MicroRNA and nephropathy: emerging concepts
por: Chung, Arthur CK, et al.
Publicado: (2013)

MicroRNAs in IgA nephropathy
por: Yao, Xingchen, et al.
Publicado: (2021)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma
por: Liu, Zhikui, et al.
Publicado: (2018)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Profiles of MicroRNAs in Interleukin–27-Induced HIV-Resistant T Cells: Identification of a Novel Antiviral MicroRNA
por: Goswami, Suranjana, et al.
Publicado: (2021)

Knockdown of microRNA-135b in Mammary Carcinoma by Targeted Nanodiamonds: Potentials and Pitfalls of In Vivo Applications
por: Křivohlavá, Romana, et al.
Publicado: (2019)

Role of Mononuclear Cells of IgA Nephropathy on ICAM-1 Expression in Mesangial Cells
por: Lee, Tae-Won, et al.
Publicado: (1998)

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes
por: Manda, Gina, et al.
Publicado: (2015)

Polyethylene Glycol 3350 Crystal Nephropathy in Association With Glomerular Mesangial Immunoglobin A Deposition
por: Aly, Rasha, et al.
Publicado: (2022)

Gut-kidney axis in IgA nephropathy: Role on mesangial cell metabolism and inflammation
por: Luvizotto, Mateus Justi, et al.
Publicado: (2022)

MicroRNA-130b attenuates dexamethasone-induced increase of lipid accumulation in porcine preadipocytes by suppressing PPAR-γ expression
por: Pan, Shifeng, et al.
Publicado: (2017)

MicroRNAs in Podocyte Injury in Diabetic Nephropathy
por: Ishii, Hiroki, et al.
Publicado: (2020)

The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy
por: Tang, Jian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5p9o3f4sk6i9ija1l2beuihcs8