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Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate

Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS,...

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Detalles Bibliográficos
Autores principales: Gao, Wei, Xu, Yongmei, Liu, Jian, Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869111/
https://www.ncbi.nlm.nih.gov/pubmed/27185050
http://dx.doi.org/10.1038/srep26245