Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

BACKGROUND: The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as CYP 2D6 poor metabolizer status and/or co-administration of drugs that inhibit/interact with CYP 2D6 could alter the pha...

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Detalles Bibliográficos
Autores principales: Jin, Xiannu, Potter, Brittney, Luong, Thu-lan, Nelson, Jennifer, Vuong, Chau, Potter, Corttney, Xie, Lisa, Zhang, Jing, Zhang, Ping, Sousa, Jason, Li, Qigui, Pybus, Brandon S., Kreishman-Deitrick, Mara, Hickman, Mark, Smith, Philip L., Paris, Robert, Reichard, Gregory, Marcsisin, Sean R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869338/
https://www.ncbi.nlm.nih.gov/pubmed/27188854
http://dx.doi.org/10.1186/s12936-016-1329-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869338/
https://www.ncbi.nlm.nih.gov/pubmed/27188854
http://dx.doi.org/10.1186/s12936-016-1329-z

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