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Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants
BACKGROUND: The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as CYP 2D6 poor metabolizer status and/or co-administration of drugs that inhibit/interact with CYP 2D6 could alter the pha...
Autores principales: | Jin, Xiannu, Potter, Brittney, Luong, Thu-lan, Nelson, Jennifer, Vuong, Chau, Potter, Corttney, Xie, Lisa, Zhang, Jing, Zhang, Ping, Sousa, Jason, Li, Qigui, Pybus, Brandon S., Kreishman-Deitrick, Mara, Hickman, Mark, Smith, Philip L., Paris, Robert, Reichard, Gregory, Marcsisin, Sean R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869338/ https://www.ncbi.nlm.nih.gov/pubmed/27188854 http://dx.doi.org/10.1186/s12936-016-1329-z |
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