Cargando…

Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB

Faster elimination of drug tolerant ‘persister’ bacteria may shorten treatment of tuberculosis (TB) but no method exists to quantify persisters in clinical samples. We used automated image analysis to assess whether studying growth characteristics of individual Mycobacterium tuberculosis colonies fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barr, David A., Kamdolozi, Mercy, Nishihara, Yo, Ndhlovu, Victor, Khonga, Margaret, Davies, Geraint R., Sloan, Derek J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Churchill Livingstone 2016
Materias:	Drug Discovery and Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869592/ https://www.ncbi.nlm.nih.gov/pubmed/27156626 http://dx.doi.org/10.1016/j.tube.2016.03.001

Ejemplares similares

Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana
por: Otchere, I.D., et al.
Publicado: (2016)

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents
por: Lougheed, Kathryn E.A., et al.
Publicado: (2011)

Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis
por: Mzinza, David T., et al.
Publicado: (2015)

Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany
por: Sonnenkalb, Lindsay, et al.
Publicado: (2021)

Genetic diversity of Mycobacterium tuberculosis clinical isolates in Blantyre, Malawi
por: Ndhlovu, Victor, et al.
Publicado: (2019)

Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations
por: Liu, Xiaoxi, et al.
Publicado: (2023)

HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models
por: Gómez, Valentí, et al.
Publicado: (2022)

Optimal Strategy and Benefit of Pulsed Therapy Depend On Tumor Heterogeneity and Aggressiveness at Time of Treatment Initiation
por: Mathur, Deepti, et al.
Publicado: (2022)

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-X(L)–Specific Degrader DT2216
por: Thummuri, Dinesh, et al.
Publicado: (2022)

Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer
por: Gopinathan, Ganga, et al.
Publicado: (2022)

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
por: Coker, Elizabeth A., et al.
Publicado: (2022)

NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition
por: Llaurado Fernandez, Marta, et al.
Publicado: (2022)

Bcl-xL Is a Key Mediator of Apoptosis Following KRAS(G12C) Inhibition in KRAS(G12C)-mutant Colorectal Cancer
por: Khawaja, Hajrah, et al.
Publicado: (2023)

A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
por: Venkateswaran, Geetha, et al.
Publicado: (2023)

IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis
por: Wang, Xiao, et al.
Publicado: (2021)

Characterization of DNA methylation in Malawian Mycobacterium tuberculosis clinical isolates
por: Ndhlovu, Victor, et al.
Publicado: (2020)

Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure
por: Bhardwaj, Pooja, et al.
Publicado: (2017)

Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis
por: Shelton, Catherine, et al.
Publicado: (2022)

Analysis of Serial Isolates of mcr-1-Positive Escherichia coli Reveals a Highly Active ISApl1 Transposon
por: Snesrud, Erik, et al.
Publicado: (2017)

In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
por: McNeil, Matthew B., et al.
Publicado: (2017)

The Influence of HIV on the Evolution of Mycobacterium tuberculosis
por: Koch, Anastasia S., et al.
Publicado: (2017)

Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
por: Pitton, Melissa, et al.
Publicado: (2022)

Molecular Analysis of Linezolid-Resistant Clinical Isolates of Mycobacterium abscessus
por: Ye, Meiping, et al.
Publicado: (2019)

Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis
por: Modlin, Samuel J., et al.
Publicado: (2021)

Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis
por: Menardo, Fabrizio, et al.
Publicado: (2020)

Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance
por: Nakatani, Yoshio, et al.
Publicado: (2017)

Whole-Genome Sequencing for Drug Resistance Profile Prediction in Mycobacterium tuberculosis
por: Gygli, Sebastian M., et al.
Publicado: (2019)

MAB_2355c Confers Macrolide Resistance in Mycobacterium abscessus by Ribosome Protection
por: Guo, Qi, et al.
Publicado: (2021)

Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis
por: Shelton, Catherine D., et al.
Publicado: (2021)

Baicalein inhibits non‐small‐cell lung cancer invasion and metastasis by reducing ezrin tension in inflammation microenvironment
por: Zhang, Xiaolong, et al.
Publicado: (2020)

MET amplification results in heterogeneous responses to osimertinib in EGFR‐mutant lung cancer treated with erlotinib
por: Nishiyama, Akihiro, et al.
Publicado: (2020)

Effect of murine double‐minute 2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys
por: Kawata, Yoshiko, et al.
Publicado: (2020)

Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells
por: Ohgino, Keiko, et al.
Publicado: (2020)

Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine
por: Komoto, Kana, et al.
Publicado: (2020)

dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells
por: Yokogawa, Tatsushi, et al.
Publicado: (2020)

Extracting Atomic Contributions to Binding Free Energy using Molecular Dynamics Simulations with Mixed Solvents (MDmix)
por: Alvarez-Garcia, Daniel, et al.
Publicado: (2022)

Event Monitoring and Evaluation by Community Pharmacists in Japan: A Pilot Study on Fenofibrate and Pemafibrate
por: Takahashi, Masao, et al.
Publicado: (2022)

Key Targets and Molecular Mechanisms of Active Volatile Components of Rabdosia rubescens in Gastric Cancer Cells
por: Hu, Yanhui, et al.
Publicado: (2022)

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro
por: Patel, Nipul, et al.
Publicado: (2017)

RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus
por: Schildkraut, Jodie A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tq3flrgemch8t2rf70qle5c9rk