Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage

Sophoridine is a quinolizidine natural product of Sophora alopecuroides and has been applied for treatment of malignant trophoblastic tumors. Although characterized by low toxicity, the limited-spectrum antitumor activity hinders its further applications. 05D, a derivative of sophoridine, exhibits a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Wuli, Zhang, Caixia, Bi, Chongwen, Ye, Cheng, Song, Danqing, Liu, Xiujun, Shao, Rongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869659/
https://www.ncbi.nlm.nih.gov/pubmed/27274276
http://dx.doi.org/10.2147/OTT.S103671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869659/
https://www.ncbi.nlm.nih.gov/pubmed/27274276
http://dx.doi.org/10.2147/OTT.S103671

Ejemplares similares