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Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage
Sophoridine is a quinolizidine natural product of Sophora alopecuroides and has been applied for treatment of malignant trophoblastic tumors. Although characterized by low toxicity, the limited-spectrum antitumor activity hinders its further applications. 05D, a derivative of sophoridine, exhibits a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869659/ https://www.ncbi.nlm.nih.gov/pubmed/27274276 http://dx.doi.org/10.2147/OTT.S103671 |