Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

AIMS/HYPOTHESIS: Understanding the developmental biology of beta cell regeneration is critical for developing new diabetes therapies. Obesity is a potent but poorly understood stimulus for beta cell expansion. Current models of obesity are complicated by developmental compensation or concurrent diab...

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Detalles Bibliográficos
Autores principales: Cox, Aaron R., Lam, Carol J., Rankin, Matthew M., King, Kourtney A., Chen, Pan, Martinez, Ramon, Li, Changhong, Kushner, Jake A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869735/
https://www.ncbi.nlm.nih.gov/pubmed/27003683
http://dx.doi.org/10.1007/s00125-016-3922-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869735/
https://www.ncbi.nlm.nih.gov/pubmed/27003683
http://dx.doi.org/10.1007/s00125-016-3922-7

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