Optogenetic Acidification of Synaptic Vesicles and Lysosomes

Acidification is required for the function of many intracellular organelles, but methods to acutely manipulate their intraluminal pH have not been available. Here we present a targeting strategy to selectively express the light-driven proton pump Arch3 on synaptic vesicles. Our new tool, pHoenix, ca...

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Detalles Bibliográficos
Autores principales: Rost, Benjamin R., Schneider, Franziska, Grauel, M. Katharina, Wozny, Christian, Bentz, Claudia, Blessing, Anja, Rosenmund, Tanja, Jentsch, Thomas J., Schmitz, Dietmar, Hegemann, Peter, Rosenmund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869830/
https://www.ncbi.nlm.nih.gov/pubmed/26551543
http://dx.doi.org/10.1038/nn.4161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869830/
https://www.ncbi.nlm.nih.gov/pubmed/26551543
http://dx.doi.org/10.1038/nn.4161

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