DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

TEN-ELEVEN-TRANSLOCATION-2 (TET2) and DNA-METHYLTRANSFERASE-3A (DNMT3A), both encoding proteins involved in regulating DNA methylation, are mutated in hematological malignancies affecting both myeloid and lymphoid lineages. We previously reported an association of TET2 and DNMT3A mutations in progen...

Descripción completa

Detalles Bibliográficos
Autores principales: Scourzic, Laurianne, Couronné, Lucile, Pedersen, Marianne T., Della Valle, Véronique, Diop, M’boyba, Mylonas, Elena, Calvo, Julien, Mouly, Enguerran, Lopez, Cécile K., Martin, Nadine, Fontenay, Michaëla, Bender, Ambre, Guibert, Sylvain, Dubreuil, Patrice, Dessen, Philippe, Droin, Nathalie, Pflumio, Françoise, Weber, Michael, Gaulard, Philippe, Helin, Kristian, Mercher, Thomas, Bernard, Olivier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869893/
https://www.ncbi.nlm.nih.gov/pubmed/26876596
http://dx.doi.org/10.1038/leu.2016.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869893/
https://www.ncbi.nlm.nih.gov/pubmed/26876596
http://dx.doi.org/10.1038/leu.2016.29

Ejemplares similares