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Practical Radiosynthesis and Preclinical Neuroimaging of [(11)C]isradipine, a Calcium Channel Antagonist

In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca(2+)-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,2,5]oxadiazol-4-yl)-5-(isopropoxycarbonyl)-2...

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Detalles Bibliográficos
Autores principales: Rotstein, Benjamin H., Liang, Steven H., Belov, Vasily V., Livni, Eli, Levine, Dylan B., Bonab, Ali A., Papisov, Mikhail I., Perlis, Roy H., Vasdev, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870226/
https://www.ncbi.nlm.nih.gov/pubmed/26016546
http://dx.doi.org/10.3390/molecules20069550