Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined how commonly occurring single site mutations in pa...

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Detalles Bibliográficos
Autores principales: Sagatova, Alia A., Keniya, Mikhail V., Wilson, Rajni K., Sabherwal, Manya, Tyndall, Joel D. A., Monk, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870556/
https://www.ncbi.nlm.nih.gov/pubmed/27188873
http://dx.doi.org/10.1038/srep26213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870556/
https://www.ncbi.nlm.nih.gov/pubmed/27188873
http://dx.doi.org/10.1038/srep26213

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