Cargando…

Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening

Mitochondrial dysfunction and oxidative stress are the major events that lead to the formation of mitochondrial permeability transition pore (mPTP) during glutamate-induced cytotoxicity and cell death. Coenzyme Q10 (CoQ10) has widely been used for the treatment of mitochondrial disorders and neurode...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumari, Santosh, Mehta, Suresh L, Milledge, Gaolin Z., Huang, Xinyu, Li, Haining, Li, P. Andy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870712/ https://www.ncbi.nlm.nih.gov/pubmed/27194946 http://dx.doi.org/10.7150/ijbs.13589

Ejemplares similares

Ubisol Coenzyme Q10 promotes mitochondrial biogenesis in HT22 cells challenged by glutamate
por: Zimmerman, Mary A., et al.
Publicado: (2021)

Orally delivered water soluble Coenzyme Q(10) (Ubisol-Q(10)) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
por: Muthukumaran, Krithika, et al.
Publicado: (2014)

Correction to: Orally delivered water soluble coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
por: Muthukumaran, Krithika, et al.
Publicado: (2021)

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium
por: Kumari, Santosh, et al.
Publicado: (2012)

Ubisol-Q(10), a Nanomicellar and Water-Dispersible Formulation of Coenzyme-Q(10) as a Potential Treatment for Alzheimer’s and Parkinson’s Disease
por: Wear, Darcy, et al.
Publicado: (2021)

Resumption of Autophagy by Ubisol-Q(10) in Presenilin-1 Mutated Fibroblasts and Transgenic AD Mice: Implications for Inhibition of Senescence and Neuroprotection
por: Vegh, Caleb, et al.
Publicado: (2019)

Combined Ubisol-Q(10) and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinson’s Disease
por: Vegh, Caleb, et al.
Publicado: (2021)

Mutation-induced Blocker Permeability and Multiion Block of the CFTR Chloride Channel Pore
por: Gong, Xiandi, et al.
Publicado: (2003)

Regulation of mitochondrial permeability transition pore by PINK1
por: Giaime, Emilie, et al.
Publicado: (2012)

The mitochondrial permeability transition pore: a mystery solved?
por: Bernardi, Paolo
Publicado: (2013)

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria
por: Rottenberg, Hagai, et al.
Publicado: (2001)

Dual dynamics of mitochondrial permeability transition pore opening
por: Wacquier, Benjamin, et al.
Publicado: (2020)

The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria★
por: Yu, Ning, et al.
Publicado: (2012)

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
por: Varanyuwatana, Pinadda, et al.
Publicado: (2012)

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology
por: Bonora, Massimo, et al.
Publicado: (2020)

Regulation of the mitochondrial permeability transition pore and its effects on aging
por: Pellegrino-Coppola, Damiano
Publicado: (2020)

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore
por: Morciano, Giampaolo, et al.
Publicado: (2022)

Mitochondrial Cyclosporine A-Independent Palmitate/Ca(2+)-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity
por: Mironova, Galina D., et al.
Publicado: (2021)

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
por: Quintanilla, Rodrigo A, et al.
Publicado: (2013)

The mitochondrial permeability transition pore and its adaptive responses in tumor cells
por: Rasola, Andrea, et al.
Publicado: (2014)

Other bricks for the correct construction of the mitochondrial permeability transition pore complex
por: Morciano, Giampaolo, et al.
Publicado: (2017)

Involvement of Multidrug Resistance Modulators in the Regulation of the Mitochondrial Permeability Transition Pore
por: Fedotcheva, Tatiana, et al.
Publicado: (2022)

Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening
por: Bhosale, Gauri, et al.
Publicado: (2019)

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species
por: Frigo, Elena, et al.
Publicado: (2023)

Glutamate Permeability of Chicken Best1
por: Lee, Jung Moo, et al.
Publicado: (2022)

Investigation on the Air Permeability and Pore Structure of Concrete Subjected to Carbonation under Compressive Stress
por: Zhang, Cheng, et al.
Publicado: (2022)

How Pore Hydrophilicity Influences Water Permeability?
por: Xu, Fang, et al.
Publicado: (2019)

Mitochondrial permeability transition pore as a selective target for anti-cancer therapy
por: Suh, Dong H., et al.
Publicado: (2013)

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux
por: De Marchi, Elena, et al.
Publicado: (2014)

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration
por: Savino, Costanza, et al.
Publicado: (2013)

Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore
por: Bernardi, Paolo, et al.
Publicado: (2015)

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection
por: Bernardi, Paolo, et al.
Publicado: (2015)

Inhibition of mitochondrial permeability transition pore restores the cardioprotection by postconditioning in diabetic hearts
por: Najafi, Moslem, et al.
Publicado: (2014)

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death
por: Bonora, Massimo, et al.
Publicado: (2014)

Mitochondrial DNA Mutations Cause Disease, Apoptosis, and Permeability Transition Pore Dysfunction
por: Justin, L. Mott, et al.
Publicado: (2001)

Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury
por: Springer, Joe E., et al.
Publicado: (2018)

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
por: Briston, Thomas, et al.
Publicado: (2017)

The very low number of calcium-induced permeability transition pores in the single mitochondrion
por: Neginskaya, Maria A., et al.
Publicado: (2020)

Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia
por: Sambri, Irene, et al.
Publicado: (2020)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l2iusj1jv5thmmfico92uf73cs