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A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation
To mediate the degradation of bio-macromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal Ca(2+) channel TRPML1 cause lysosome storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cell...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871318/ https://www.ncbi.nlm.nih.gov/pubmed/26950892 http://dx.doi.org/10.1038/ncb3324 |