Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

Although the predominant effect of host restriction APOBEC3 proteins on HIV-1 infection is to block viral replication, they might inadvertently increase retroviral genetic variation by inducing G-to-A hypermutation. Numerous studies have disagreed on the contribution of hypermutation to viral geneti...

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Detalles Bibliográficos
Autores principales: Delviks-Frankenberry, Krista A., Nikolaitchik, Olga A., Burdick, Ryan C., Gorelick, Robert J., Keele, Brandon F., Hu, Wei-Shau, Pathak, Vinay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871359/
https://www.ncbi.nlm.nih.gov/pubmed/27186986
http://dx.doi.org/10.1371/journal.ppat.1005646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871359/
https://www.ncbi.nlm.nih.gov/pubmed/27186986
http://dx.doi.org/10.1371/journal.ppat.1005646

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