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Podocyte Depletion in Thin GBM and Alport Syndrome

The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in urine is increased in AS, suggesting that pod...

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Detalles Bibliográficos
Autores principales: Wickman, Larysa, Hodgin, Jeffrey B., Wang, Su Q., Afshinnia, Farsad, Kershaw, David, Wiggins, Roger C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871445/
https://www.ncbi.nlm.nih.gov/pubmed/27192434
http://dx.doi.org/10.1371/journal.pone.0155255