Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson’s Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson’s disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight of these...

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Detalles Bibliográficos
Autores principales: Momcilovic, Olga, Sivapatham, Renuka, Oron, Tal Ronnen, Meyer, Morten, Mooney, Sean, Rao, Mahendra S., Zeng, Xianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871453/
https://www.ncbi.nlm.nih.gov/pubmed/27191603
http://dx.doi.org/10.1371/journal.pone.0154890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871453/
https://www.ncbi.nlm.nih.gov/pubmed/27191603
http://dx.doi.org/10.1371/journal.pone.0154890

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