A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which exhibits several non-optimal features. These shortcomings underpin the need for next generation anthelmintics, but the process of validating phys...

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Detalles Bibliográficos
Autores principales: Chan, John D., McCorvy, John D., Acharya, Sreemoyee, Johns, Malcolm E., Day, Timothy A., Roth, Bryan L., Marchant, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871480/
https://www.ncbi.nlm.nih.gov/pubmed/27187180
http://dx.doi.org/10.1371/journal.ppat.1005651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871480/
https://www.ncbi.nlm.nih.gov/pubmed/27187180
http://dx.doi.org/10.1371/journal.ppat.1005651

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