Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism g...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheng, Zizhang, Schramm, Chaim A., Connors, Mark, Morris, Lynn, Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871536/
https://www.ncbi.nlm.nih.gov/pubmed/27191167
http://dx.doi.org/10.1371/journal.pcbi.1004940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871536/
https://www.ncbi.nlm.nih.gov/pubmed/27191167
http://dx.doi.org/10.1371/journal.pcbi.1004940

Ejemplares similares