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Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism g...

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Detalles Bibliográficos
Autores principales:	Sheng, Zizhang, Schramm, Chaim A., Connors, Mark, Morris, Lynn, Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871536/ https://www.ncbi.nlm.nih.gov/pubmed/27191167 http://dx.doi.org/10.1371/journal.pcbi.1004940

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