Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF

The physiological functions of vitamin D are mediated by its metabolite 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) activating the transcription factor vitamin D receptor (VDR). In THP-1 human monocytes we demonstrated epigenome-wide effects of 1,25(OH)(2)D(3) at 8979 loci with significantly modul...

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Detalles Bibliográficos
Autores principales: Seuter, Sabine, Neme, Antonio, Carlberg, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872072/
https://www.ncbi.nlm.nih.gov/pubmed/26715761
http://dx.doi.org/10.1093/nar/gkv1519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872072/
https://www.ncbi.nlm.nih.gov/pubmed/26715761
http://dx.doi.org/10.1093/nar/gkv1519

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