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Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF
The physiological functions of vitamin D are mediated by its metabolite 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) activating the transcription factor vitamin D receptor (VDR). In THP-1 human monocytes we demonstrated epigenome-wide effects of 1,25(OH)(2)D(3) at 8979 loci with significantly modul...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872072/ https://www.ncbi.nlm.nih.gov/pubmed/26715761 http://dx.doi.org/10.1093/nar/gkv1519 |