Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthesis (TLS) and the Fanconi Anemia (FA) pathway. However, physiological roles of Rad18 in DNA damage tolerance and carcinogenesis are unknown and were investigated here. Primary hematopoietic stem and progenitor cells...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Poe, Jonathan C., Yang, Lisong, Fedoriw, Andrew, Desai, Siddhi, Magnuson, Terry, Li, Zhiguo, Fedoriw, Yuri, Araki, Kimi, Gao, Yanzhe, Tateishi, Satoshi, Sarantopoulos, Stefanie, Vaziri, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872084/
https://www.ncbi.nlm.nih.gov/pubmed/26883629
http://dx.doi.org/10.1093/nar/gkw072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872084/
https://www.ncbi.nlm.nih.gov/pubmed/26883629
http://dx.doi.org/10.1093/nar/gkw072

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