Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic transcription. Writer and eraser enzymes establish and maintain the epigenetic code by creating or removing posttranslational marks. Specific binding proteins, called readers, recognize the modifications...

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Detalles Bibliográficos
Autores principales: Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872087/
https://www.ncbi.nlm.nih.gov/pubmed/26893353
http://dx.doi.org/10.1093/nar/gkw089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872087/
https://www.ncbi.nlm.nih.gov/pubmed/26893353
http://dx.doi.org/10.1093/nar/gkw089

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