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Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform
Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic transcription. Writer and eraser enzymes establish and maintain the epigenetic code by creating or removing posttranslational marks. Specific binding proteins, called readers, recognize the modifications...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872087/ https://www.ncbi.nlm.nih.gov/pubmed/26893353 http://dx.doi.org/10.1093/nar/gkw089 |