Rational design of novel N-alkyl-N capped biostable RNA nanostructures for efficient long-term inhibition of gene expression

Computational techniques have been used to design a novel class of RNA architecture with expected improved resistance to nuclease degradation, while showing interference RNA activity. The in silico designed structure consists of a 24–29 bp duplex RNA region linked on both ends by N-alkyl-N dimeric n...

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Detalles Bibliográficos
Autores principales: Terrazas, Montserrat, Ivani, Ivan, Villegas, Núria, Paris, Clément, Salvans, Cándida, Brun-Heath, Isabelle, Orozco, Modesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872095/
https://www.ncbi.nlm.nih.gov/pubmed/26975656
http://dx.doi.org/10.1093/nar/gkw169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872095/
https://www.ncbi.nlm.nih.gov/pubmed/26975656
http://dx.doi.org/10.1093/nar/gkw169

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