Cargando…

An RNA trapping mechanism in Alphavirus mRNA promotes ribosome stalling and translation initiation

During translation initiation, eukaryotic initiation factor 2 (eIF2) delivers the Met-tRNA to the 40S ribosomal subunit to locate the initiation codon (AUG(i)) of mRNA during the scanning process. Stress-induced eIF2 phosphorylation leads to a general blockade of translation initiation and represent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toribio, René, Díaz-López, Irene, Boskovic, Jasminka, Ventoso, Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872096/ https://www.ncbi.nlm.nih.gov/pubmed/26984530 http://dx.doi.org/10.1093/nar/gkw172

Ejemplares similares

Translation initiation of alphavirus mRNA reveals new insights into the topology of the 48S initiation complex
por: Toribio, René, et al.
Publicado: (2018)

SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo
por: Kim, John H, et al.
Publicado: (2022)

An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning
por: Díaz-López, Irene, et al.
Publicado: (2019)

S1 ribosomal protein and the interplay between translation and mRNA decay
por: Delvillani, Francesco, et al.
Publicado: (2011)

Facilitated leaky scanning and atypical ribosome shunting direct downstream translation initiation on the tricistronic S1 mRNA of avian reovirus
por: Racine, Trina, et al.
Publicado: (2010)

Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site
por: Starosta, Agata L., et al.
Publicado: (2014)

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain
por: Koch, Miriam, et al.
Publicado: (2017)

HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation
por: Malygin, Alexey A., et al.
Publicado: (2013)

Comparison of mRNA features affecting translation initiation and reinitiation
por: Osterman, Ilya A., et al.
Publicado: (2013)

Dyskerin depletion increases VEGF mRNA internal ribosome entry site-mediated translation
por: Rocchi, Laura, et al.
Publicado: (2013)

DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA
por: Awasthi, Sharad, et al.
Publicado: (2018)

TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation
por: Lee, Kuo-Ming, et al.
Publicado: (2010)

Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences
por: Espah Borujeni, Amin, et al.
Publicado: (2017)

The effect of RNA base lesions on mRNA translation
por: Calabretta, Alessandro, et al.
Publicado: (2015)

ArfA recognizes the lack of mRNA in the mRNA channel after RF2 binding for ribosome rescue
por: Kurita, Daisuke, et al.
Publicado: (2014)

Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length
por: Bohlen, Jonathan, et al.
Publicado: (2021)

Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation
por: Tan, Shen Mynn, et al.
Publicado: (2014)

The human translation initiation multi-factor complex promotes methionyl-tRNA(i) binding to the 40S ribosomal subunit
por: Sokabe, Masaaki, et al.
Publicado: (2012)

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
por: Kejiou, Nevraj S, et al.
Publicado: (2023)

Why base tautomerization does not cause errors in mRNA decoding on the ribosome
por: Satpati, Priyadarshi, et al.
Publicado: (2014)

Initiating ribosomes and a 5′/3′-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation
por: Braun, Frédérique, et al.
Publicado: (2017)

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
por: Svitkin, Yuri V., et al.
Publicado: (2017)

The 5′-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation
por: Vallejos, Maricarmen, et al.
Publicado: (2010)

The ribosome quality control factor Asc1 determines the fate of HSP70 mRNA on and off the ribosome
por: Alagar Boopathy, Lokha R, et al.
Publicado: (2023)

miRNA repression of translation in vitro takes place during 43S ribosomal scanning
por: Ricci, Emiliano P., et al.
Publicado: (2013)

Translation of the FMR1 mRNA is not influenced by AGG interruptions
por: Ludwig, Anna L., et al.
Publicado: (2009)

Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
por: Thomas, Erica N, et al.
Publicado: (2020)

Stimulation of ribosomal frameshifting by RNA G-quadruplex structures
por: Yu, Chien-Hung, et al.
Publicado: (2014)

In polycistronic Qβ RNA, single-strandedness at one ribosome binding site directly affects translational initiations at a distal upstream cistron
por: Jayant, Lalitha, et al.
Publicado: (2010)

Charcot–Marie–Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response
por: Mendonsa, Samantha, et al.
Publicado: (2021)

The human insulin receptor mRNA contains a functional internal ribosome entry segment
por: Spriggs, Keith A., et al.
Publicado: (2009)

Distinct tmRNA sequence elements facilitate RNase R engagement on rescued ribosomes for selective nonstop mRNA decay
por: Venkataraman, Krithika, et al.
Publicado: (2014)

The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis
por: Eastham, Matthew John, et al.
Publicado: (2023)

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
por: Anderson, Bart R., et al.
Publicado: (2010)

Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
por: Andreev, Dmitri E., et al.
Publicado: (2012)

Translational control of the interferon regulatory factor 2 mRNA by IRES element
por: Dhar, Debojyoti, et al.
Publicado: (2007)

The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation
por: Gendron, Karine, et al.
Publicado: (2008)

The Crc global regulator binds to an unpaired A-rich motif at the Pseudomonas putida alkS mRNA coding sequence and inhibits translation initiation
por: Moreno, Renata, et al.
Publicado: (2009)

Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant
por: Tsao, Douglas, et al.
Publicado: (2011)

An unstructured 5′-coding region of the prfA mRNA is required for efficient translation
por: Loh, Edmund, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cebdvcg29lr9rlil58gdlj74ma