Insertion of oxidized nucleotide triggers rapid DNA polymerase opening

A novel mechanism is unveiled to explain why a pro-mutagenic nucleotide lesion (oxidized guanine, 8-oxoG) causes the mammalian DNA repair polymerase-β (pol-β) to rapidly transition to an inactive open conformation. The mechanism involves unexpected features revealed recently in time-lapse crystallog...

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Detalles Bibliográficos
Autores principales: Kim, Taejin, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872097/
https://www.ncbi.nlm.nih.gov/pubmed/27034465
http://dx.doi.org/10.1093/nar/gkw174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872097/
https://www.ncbi.nlm.nih.gov/pubmed/27034465
http://dx.doi.org/10.1093/nar/gkw174

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