Cargando…

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening

A novel mechanism is unveiled to explain why a pro-mutagenic nucleotide lesion (oxidized guanine, 8-oxoG) causes the mammalian DNA repair polymerase-β (pol-β) to rapidly transition to an inactive open conformation. The mechanism involves unexpected features revealed recently in time-lapse crystallog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Taejin, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872097/ https://www.ncbi.nlm.nih.gov/pubmed/27034465 http://dx.doi.org/10.1093/nar/gkw174

Ejemplares similares

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition
por: Smith, Mallory R, et al.
Publicado: (2019)

Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide
por: Freudenthal, Bret D., et al.
Publicado: (2014)

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide
por: Whitaker, Amy M., et al.
Publicado: (2017)

Processing oxidatively damaged bases at DNA strand breaks by APE1
por: Whitaker, Amy M, et al.
Publicado: (2022)

Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide
por: Singh, Isha, et al.
Publicado: (2018)

Watching a DNA polymerase in action
por: Freudenthal, Bret D, et al.
Publicado: (2014)

Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda
por: Burak, Matthew J., et al.
Publicado: (2015)

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion
por: Freudenthal, Bret D., et al.
Publicado: (2013)

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction
por: Shock, David D., et al.
Publicado: (2017)

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
por: Jamsen, Joonas A., et al.
Publicado: (2021)

Revealing the role of the product metal in DNA polymerase β catalysis
por: Perera, Lalith, et al.
Publicado: (2017)

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state
por: Surana, Parag, et al.
Publicado: (2014)

Deaminated purine bypass by DNA polymerase η
por: Andreeva, Antonina
Publicado: (2021)

A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation
por: Ooi, Wei-Yang, et al.
Publicado: (2018)

Structural basis of DNA polymerase θ mediated DNA end joining
por: Li, Chuxuan, et al.
Publicado: (2022)

Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA
por: Wojtas, Magdalena N., et al.
Publicado: (2012)

Structural basis for the D-stereoselectivity of human DNA polymerase β
por: Vyas, Rajan, et al.
Publicado: (2017)

The proofreading exonuclease subunit ε of Escherichia coli DNA polymerase III is tethered to the polymerase subunit α via a flexible linker
por: Ozawa, Kiyoshi, et al.
Publicado: (2008)

Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase
por: Kirouac, Kevin N., et al.
Publicado: (2013)

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu
por: Moon, Andrea F., et al.
Publicado: (2017)

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β
por: Koag, Myong-Chul, et al.
Publicado: (2014)

Classification of pseudo pairs between nucleotide bases and amino acids by analysis of nucleotide–protein complexes
por: Kondo, Jiro, et al.
Publicado: (2011)

Distinct energetics and closing pathways for DNA polymerase β with 8-oxoG template and different incoming nucleotides
por: Wang, Yanli, et al.
Publicado: (2007)

“Gate-keeper” Residues and Active-Site Rearrangements in DNA Polymerase μ Help Discriminate Non-cognate Nucleotides
por: Li, Yunlang, et al.
Publicado: (2013)

Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase
por: James, Tamara D., et al.
Publicado: (2016)

Thumb-domain dynamics modulate the functional repertoire of DNA-Polymerase IV (DinB)
por: Okeke, Damasus C, et al.
Publicado: (2023)

Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations
por: Azad, Robert N, et al.
Publicado: (2018)

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase
por: Dehghani-Tafti, Saba, et al.
Publicado: (2019)

Modular architecture of nucleotide-binding pockets
por: Gherardini, Pier Federico, et al.
Publicado: (2010)

Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase
por: Ren, Zhong
Publicado: (2016)

Structure of an inactive RNA polymerase II dimer
por: Aibara, Shintaro, et al.
Publicado: (2021)

Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors
por: Sanders, Cyril M., et al.
Publicado: (2007)

A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping
por: Earl, Christopher, et al.
Publicado: (2018)

Solution structures of 2 : 1 and 1 : 1 DNA polymerase–DNA complexes probed by ultracentrifugation and small-angle X-ray scattering
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

G-quadruplex formation at the 3′ end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase
por: Wang, Quan, et al.
Publicado: (2011)

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli
por: Sharma, Amit, et al.
Publicado: (2013)

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility
por: Powers, Kyle T, et al.
Publicado: (2018)

Structural dynamics and determinants of 2-aminoadenine specificity in DNA polymerase DpoZ of vibriophage ϕVC8
por: Czernecki, Dariusz, et al.
Publicado: (2021)

Structure of the bacteriophage PhiKZ non-virion RNA polymerase
por: de Martín Garrido, Natàlia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kn0rof0628q6jaavaiqefd0fjh