Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis

Heterocyclic dications are receiving increasing attention as targeted inhibitors of transcription factors. While many dications act as purely competitive inhibitors, some fail to displace protein efficiently at drug concentrations expected to saturate their DNA target. To achieve a mechanistic under...

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Detalles Bibliográficos
Autores principales: Stephens, Dominique C., Kim, Hye Mi, Kumar, Arvind, Farahat, Abdelbasset A., Boykin, David W., K. Poon, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872103/
https://www.ncbi.nlm.nih.gov/pubmed/27079976
http://dx.doi.org/10.1093/nar/gkw229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872103/
https://www.ncbi.nlm.nih.gov/pubmed/27079976
http://dx.doi.org/10.1093/nar/gkw229

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