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DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) acquire new spacers to generate adaptive immunity in prokaryotes. During spacer integration, the leader-preceded repeat is always accurately duplicated, leading to speculations of a repeat-length ruler. Here in Haloarcula hispanica,...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Li, Ming, Gong, Luyao, Hu, Songnian, Xiang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872114/
https://www.ncbi.nlm.nih.gov/pubmed/27085805
http://dx.doi.org/10.1093/nar/gkw260