Mechanistic insight into cadmium-induced inactivation of the Bloom protein

Cadmium is a toxic metal that inactivates DNA-repair proteins via multiple mechanisms, including zinc substitution. In this study, we investigated the effect of Cd(2+) on the Bloom protein (BLM), a DNA-repair helicase carrying a zinc-binding domain (ZBD) and playing a critical role to ensure genomic...

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Detalles Bibliográficos
Autores principales: Qin, Wei, Bazeille, Nicolas, Henry, Etienne, Zhang, Bo, Deprez, Eric, Xi, Xu-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872126/
https://www.ncbi.nlm.nih.gov/pubmed/27194376
http://dx.doi.org/10.1038/srep26225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872126/
https://www.ncbi.nlm.nih.gov/pubmed/27194376
http://dx.doi.org/10.1038/srep26225

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