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Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning

BACKGROUND: Obesity can lead to cognitive dysfunction including poor performance in memory tasks. However, poor memory is not seen in all obese humans and takes several months to develop in animal models, indicating the adult brain is relatively resistant to obesity’s cognitive effects. We have seen...

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Detalles Bibliográficos
Autores principales: De Luca, Simone N., Ziko, Ilvana, Sominsky, Luba, Nguyen, Jason C. D., Dinan, Tara, Miller, Alyson A., Jenkins, Trisha A., Spencer, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872342/
https://www.ncbi.nlm.nih.gov/pubmed/27193330
http://dx.doi.org/10.1186/s12974-016-0578-7