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Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis
BACKGROUND: Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are large...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872343/ https://www.ncbi.nlm.nih.gov/pubmed/27198694 http://dx.doi.org/10.1186/s13073-016-0310-3 |