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2-arachidonoylglycerol signaling impairs short-term fear extinction

Impairments in fear extinction are thought to be central to the psychopathology of posttraumatic stress disorder, and endocannabinoid (eCB) signaling has been strongly implicated in extinction learning. Here we utilized the monoacylglycerol lipase inhibitor JZL184 to selectively augment brain 2-AG l...

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Detalles Bibliográficos
Autores principales: Hartley, N D, Gunduz-Cinar, O, Halladay, L, Bukalo, O, Holmes, A, Patel, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872450/
https://www.ncbi.nlm.nih.gov/pubmed/26926885
http://dx.doi.org/10.1038/tp.2016.26