Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

JMJD2B is a histone demethylase enzyme that regulates gene expression through demethylation of H3K9me3. Although mutations of JMJD2B have been suggested to be responsible for neurodevelopmental disorders, the function of JMJD2B in the central nervous system (CNS) remains to be elucidated. Here we sh...

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Detalles Bibliográficos
Autores principales: Fujiwara, K, Fujita, Y, Kasai, A, Onaka, Y, Hashimoto, H, Okada, H, Yamashita, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872455/
https://www.ncbi.nlm.nih.gov/pubmed/27023172
http://dx.doi.org/10.1038/tp.2016.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872455/
https://www.ncbi.nlm.nih.gov/pubmed/27023172
http://dx.doi.org/10.1038/tp.2016.31

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