An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treat...

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Detalles Bibliográficos
Autores principales: Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872591/
https://www.ncbi.nlm.nih.gov/pubmed/27060763
http://dx.doi.org/10.1016/j.ejmech.2016.03.064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872591/
https://www.ncbi.nlm.nih.gov/pubmed/27060763
http://dx.doi.org/10.1016/j.ejmech.2016.03.064

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