R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation

DNA polymerase β (Pol β) is a key enzyme in DNA base excision repair (BER), a pathway that maintains genome integrity and stability. Pol β mutations have been detected in various types of cancers, suggesting a possible linkage between Pol β mutations and cancer. However, it is not clear whether and...

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Detalles Bibliográficos
Autores principales: Zhou, Ting, Pan, Feiyan, Cao, Yan, Han, Ying, Zhao, Jing, Sun, Hongfang, Zhou, Xiaolong, Wu, Xuping, He, Lingfeng, Hu, Zhigang, Chen, Haoyan, Shen, Binghui, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872757/
https://www.ncbi.nlm.nih.gov/pubmed/26760506
http://dx.doi.org/10.18632/oncotarget.6849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872757/
https://www.ncbi.nlm.nih.gov/pubmed/26760506
http://dx.doi.org/10.18632/oncotarget.6849

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