Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

KIF3A, a component of the kinesin-2 motor, is necessary for the progression of diverse tumor types. This is partly due to its role in regulating ciliogenesis and cell responsiveness to sonic hedgehog (SHH). Notably, primary cilia have been detected in human glioblastoma multiforme (GBM) tumor biopsi...

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Detalles Bibliográficos
Autores principales: Hoang-Minh, Lan B., Deleyrolle, Loic P., Siebzehnrubl, Dorit, Ugartemendia, George, Futch, Hunter, Griffith, Benjamin, Breunig, Joshua J., De Leon, Gabriel, Mitchell, Duane A., Semple-Rowland, Susan, Reynolds, Brent A., Sarkisian, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872766/
https://www.ncbi.nlm.nih.gov/pubmed/26760767
http://dx.doi.org/10.18632/oncotarget.6854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872766/
https://www.ncbi.nlm.nih.gov/pubmed/26760767
http://dx.doi.org/10.18632/oncotarget.6854

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