miRNA-29a as a tumor suppressor mediates PRIMA-1(Met)-induced anti-myeloma activity by targeting c-Myc

The proto-oncogene c-Myc plays substantial role in multiple myeloma (MM) pathogenesis and is considered a potential drug target. Here we provide evidence of a novel mechanism for PRIMA-1(Met), a small molecule with anti-tumor activity in phase I/II clinical trial, showing that PRIMA-1(Met) induces a...

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Detalles Bibliográficos
Autores principales: Saha, Manujendra N., Abdi, Jahangir, Yang, Yijun, Chang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872775/
https://www.ncbi.nlm.nih.gov/pubmed/26771839
http://dx.doi.org/10.18632/oncotarget.6880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872775/
https://www.ncbi.nlm.nih.gov/pubmed/26771839
http://dx.doi.org/10.18632/oncotarget.6880

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