CXCR2 signaling regulates KRAS((G12D))-induced autocrine growth of pancreatic cancer

Pharmacological inhibition of RAS, the master regulator of pancreatic ductal adenocarcinoma (PDAC), continues to be a challenge. Mutations in various isoforms of RAS gene, including KRAS are known to upregulate CXC chemokines; however, their precise role in KRAS-driven pancreatic cancer remains uncl...

Descripción completa

Detalles Bibliográficos
Autores principales: Purohit, Abhilasha, Varney, Michelle, Rachagani, Satyanarayana, Ouellette, Michel M., Batra, Surinder K., Singh, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872785/
https://www.ncbi.nlm.nih.gov/pubmed/26771140
http://dx.doi.org/10.18632/oncotarget.6906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872785/
https://www.ncbi.nlm.nih.gov/pubmed/26771140
http://dx.doi.org/10.18632/oncotarget.6906

Ejemplares similares