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CXCR2 signaling regulates KRAS((G12D))-induced autocrine growth of pancreatic cancer

Pharmacological inhibition of RAS, the master regulator of pancreatic ductal adenocarcinoma (PDAC), continues to be a challenge. Mutations in various isoforms of RAS gene, including KRAS are known to upregulate CXC chemokines; however, their precise role in KRAS-driven pancreatic cancer remains uncl...

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Detalles Bibliográficos
Autores principales:	Purohit, Abhilasha, Varney, Michelle, Rachagani, Satyanarayana, Ouellette, Michel M., Batra, Surinder K., Singh, Rakesh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872785/ https://www.ncbi.nlm.nih.gov/pubmed/26771140 http://dx.doi.org/10.18632/oncotarget.6906

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