Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

Oncogenic NRAS mutations are frequent in melanoma and lead to increased downstream signaling and uncontrolled cell proliferation. Since the direct inhibition of NRAS is not possible yet, modulators of NRAS posttranslational modifications have become an area of interest. Specifically, interfering wit...

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Detalles Bibliográficos
Autores principales: Vujic, Igor, Sanlorenzo, Martina, Esteve-Puig, Rosaura, Vujic, Marin, Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Moy, Adrian, Posch, Christian, Monshi, Babak, Rappersberger, Klemens, Ortiz-Urda, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872786/
https://www.ncbi.nlm.nih.gov/pubmed/26771141
http://dx.doi.org/10.18632/oncotarget.6907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872786/
https://www.ncbi.nlm.nih.gov/pubmed/26771141
http://dx.doi.org/10.18632/oncotarget.6907

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