Cargando…

Comparison of liver oncogenic potential among human RAS isoforms

Mutation in one of three RAS genes (i.e., HRAS, KRAS, and NRAS) leading to constitutive activation of RAS signaling pathways is considered a key oncogenic event in human carcinogenesis. Whether activated RAS isoforms possess different oncogenic potentials remains an unresolved question. Here, we com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Sook In, Moon, Hyuk, Ju, Hye-Lim, Kim, Dae Yeong, Cho, Kyung Joo, Ribback, Silvia, Dombrowski, Frank, Calvisi, Diego F., Ro, Simon Weonsang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872791/ https://www.ncbi.nlm.nih.gov/pubmed/26799184 http://dx.doi.org/10.18632/oncotarget.6931

Ejemplares similares

Transgenic mouse model expressing P53(R172H), luciferase, EGFP, and KRAS(G12D) in a single open reading frame for live imaging of tumor
por: Ju, Hye-Lim, et al.
Publicado: (2015)

Ras Mitogen-activated Protein Kinase Signaling and Kinase Suppressor of Ras as Therapeutic Targets for Hepatocellular Carcinoma
por: Moon, Hyuk, et al.
Publicado: (2021)

Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background
por: Chung, Sook In, et al.
Publicado: (2016)

Knockdown of Atg7 suppresses Tumorigenesis in a murine model of liver cancer
por: Cho, Kyung Joo, et al.
Publicado: (2021)

Investigation of Oncogenic Cooperation in Simple Liver-Specific Transgenic Mouse Models Using Noninvasive In Vivo Imaging
por: Ju, Hye-Lim, et al.
Publicado: (2013)

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice
por: Delogu, Salvatore, et al.
Publicado: (2014)

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model
por: Dong, Mingjie, et al.
Publicado: (2018)

Making cancer fat: reprogramming of lipid metabolism by CD147 in hepatocellular carcinoma
por: Ju, Hye-Lim, et al.
Publicado: (2016)

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
por: Moon, Hyuk, et al.
Publicado: (2021)

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice
por: Li, Lei, et al.
Publicado: (2013)

Early Subcellular Hepatocellular Alterations in Mice Post Hydrodynamic Transfection: An Explorative Study
por: Yasser, Mohd, et al.
Publicado: (2023)

Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma
por: Cho, Kyungjoo, et al.
Publicado: (2021)

Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms
por: Bauer, Julia, et al.
Publicado: (2021)

Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail
por: Moon, Hyuk, et al.
Publicado: (2017)

PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men
por: Ribback, Silvia, et al.
Publicado: (2015)

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice
por: Ribback, Silvia, et al.
Publicado: (2017)

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development
por: Liu, Pin, et al.
Publicado: (2017)

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
por: Grassilli, E, et al.
Publicado: (2016)

Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer
por: Wang, Chunmei, et al.
Publicado: (2013)

Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism
por: Metzendorf, Christoph, et al.
Publicado: (2020)

Inhibition of MELK Protooncogene as an Innovative Treatment for Intrahepatic Cholangiocarcinoma
por: Cigliano, Antonio, et al.
Publicado: (2019)

CD147/Basigin: a Warburg oncogene in hepatocellular carcinoma?
por: Calvisi, Diego Francesco
Publicado: (2016)

Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors
por: Park, Hyunjung, et al.
Publicado: (2022)

Targeting EGFR/PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma
por: Bang, Jieun, et al.
Publicado: (2023)

Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications
por: Park, Hyunjung, et al.
Publicado: (2023)

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
por: Xu, Zhong, et al.
Publicado: (2018)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
por: Sheffels, Erin, et al.
Publicado: (2021)

High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
por: Moon, Hyuk, et al.
Publicado: (2019)

Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways
por: Moon, Hyuk, et al.
Publicado: (2022)

Ras protein abundance correlates with Ras isoform mutation patterns in cancer
por: Hood, Fiona E., et al.
Publicado: (2023)

Transforming ras oncogenes and multistage carcinogenesis.
por: Balmain, A.
Publicado: (1985)

Ras oncogene mutation in multiple myeloma
Publicado: (1989)

RAS: Striking at the Core of the Oncogenic Circuitry
por: Gimple, Ryan C., et al.
Publicado: (2019)

The impact of oncogenic RAS on redox balance and implications for cancer development
por: Lim, Jonathan K. M., et al.
Publicado: (2019)

Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains
por: Augsten, Martin, et al.
Publicado: (2014)

Role of Ras isoforms in γδ T-cell development
por: Marín-Marín, Ana V, et al.
Publicado: (2012)

Absolute Quantification of Endogenous Ras Isoform Abundance
por: Mageean, Craig J., et al.
Publicado: (2015)

Decoding RAS isoform and codon-specific signalling
por: Newlaczyl, Anna U., et al.
Publicado: (2014)

The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models
por: Ribback, Silvia, et al.
Publicado: (2016)

Genetically Engineered Mouse Models for Liver Cancer
por: Cho, Kyungjoo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_701nfj44umro6vvmfet9r3q0lc